RAF Typhoon jets have operated alongside France's air force in a combined operation targeting an hidden munitions depot in Syrian territory used by the Daesh militant organization, according to the UK's MoD.
The location, pinpointed through surveillance, was thought to be containing munitions and bombs, the release indicated, and was situated in hills just to the north of Palmyra in the heart of Syria.
"Our fighter planes employed laser-guided Paveway IV weapons to hit a several entry passages down to the depot... initial indications suggest the objective was successfully hit," the MoD said.
There was no indication of any harm to civilians in the strike late on Saturday and all the aircraft returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were backed up by a Voyager tanker plane.
Daesh - referred to as the so-called Islamic State - established jihadist rule over parts of Iraq and Syria prior to its 2019 collapse.
"This strike underscores British leadership, and commitment to stand shoulder to shoulder with our allies, to eradicate any revival of Daesh and their dangerous and violent ideologies in the area," Britain's Defence Chief the minister said.
UK warplanes have performed surveillance missions over Syria to "forestall any attempted comeback" of Islamic State following its military defeat at the climactic battle in Baghuz in 2019, the MoD reported.
"I extend gratitude to the personnel of our armed forces participating in this mission for their professionalism and their courage," the Defence Secretary added. "Including them were numerous British personnel stationed over Christmas and New Year. This action, to remove dangerous terrorists who threaten our way of life, demonstrates how British military are always on standby, continuously, protecting the UK at home and strong abroad."
Last December, the United States armed forces executed what it described as a "major assault" on Islamic State objectives in Syria, following an attack killed two American soldiers and a civilian interpreter in Palmyra.
The UN estimates IS still has roughly 5-7 thousand combatants in Iraq and Syria.